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Background: The mechanisms that underlie adverse cardiovascular outcomes in diabetic patients have not been well characterized. Methods: A systematic analysis was performed in 2,237 subjects in randomized controlled studies of atherosclerosis progression. The pattern of arterial remodeling, extent of coronary atherosclerosis, and disease progression was…

Background: Antral pulmonary vein (PV) ablation with radiofrequency energy is widely used as a strategy for catheter ablation of paroxysmal atrial fibrillation (PAF). A novel double lumen cryoballoon catheter was designed for circumferential pulmonary vein isolation (PVI) with the cryoablation technique. Methods: We consecutively enrolled…

The aim of this study was to investigate the association between an exaggerated blood pressure (BP) response to exercise and augmented angiotensin (Ang) II rise during exercise. Although a central pressor effect of Ang II has been implicated in the pathogenesis of hypertension, the relationship…

Boston, MA – The consumption of a diet containing vegetable oils rich in alpha-linolenic acid (ALA) is associated with significant reductions in the risk of nonfatal MI, a new study has shown [1]. Investigators say the protective effect of ALA is evident among individuals with…

Berlin, Germany – A new analysis from the blood-pressure-lowering part of the ADVANCE trial in patients with type 2 diabetes shows that the fixed-dose combination antihypertensive perindopril/indapamide (Servier) slowed the development or progression of renal disease compared with placebo, even in patients whose initial blood…

London, UK – Results from a substudy of the Hypertension in the Very Elderly Trial (HYVET), the HYVET-cognitive function assessment (HYVET-COG), suggest that lowering blood pressure in individuals aged 80 and older might reduce dementia risk [1]. When combined with results from other placebo-controlled trials,…

Basel, Switzerland – Novartis has announced that it intends to acquire Speedel, the company that holds the rights to the renin inhibitor aliskiren (Tekturna/Rasilez), which Novartis already markets as an antihypertensive under a license agreement [1]. With the acquisition, Novartis would gain greater flexibility and…

Atlanta, GA – Coronary heart disease has a significant impact on health-related quality of life, a new study shows [1]. Furthermore, there are big variations in quality of life across different subgroups of people with CHD—for example, by age and by race, say Dr Jipan…

Edinburgh, Scotland – Measurement of the ankle-brachial index (ABI) may improve the accuracy of cardiovascular risk prediction beyond the Framingham risk score, a new meta-analysis suggests [1]. The analysis, published in the July 9, 2008 issue of the Journal of the American Medical Association, was…